Mass Spectrometry for GC

Topics of the course

• Terminology and concept in mass spectrometry
• Design and operation (interface, ion source, pumps, detectors)
• Optimal information with Full-Scan, SIM and mass chromatograms
• The importance of proper tuning and mass calibration
• Low resolution versus High resolution and Mass Accuracy
• Quadrupole, iontrap, TOF, triple quad and orbitrap technology
• Points to consider for proper qualification and quantification, including Quan ions, qual ions, ion ratio confirmation, library search and library construction
• Important GC parameters for GC-MS
• Low bleed capillary columns for GC-MS
• Practice on GC-MS and GC-MS²: Full Scan vs SIM vs MS²
• Practice: independent method development for a GC-MS system